The movie picks up where the first installment left off, with Edward and his family leaving Forks in an attempt to protect Bella from the dangers of the vampire world. However, Bella soon finds herself drawn to Jacob Black (Taylor Lautner), a werewolf and a friend of her late father. As she spends more time with Jacob, she begins to realize her feelings for him.

The movie also launched the careers of Kristen Stewart and Robert Pattinson, who became household names following the success of the Twilight Saga.

Meanwhile, Victoria (Rachelle Lefevre), James's (Cam Gigandet) partner, seeks revenge for James's death at the hands of Edward. Victoria creates an army of "newborn" vampires to attack Bella and the Cullens.