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The fourth season continues the story of Sam and Dean as they deal with the aftermath of Lucifer's release. The season introduces the concept of Apocalypse, as the brothers work to prevent the end of the world.

Season 9 sees Sam and Dean facing off against a new enemy: the Darkness. The season also explores the show's mythology, including the introduction of the Nephilim.

Season 13 sees Sam and Dean facing off against a new enemy: the Shomeh. The season also explores the show's mythology, including the introduction of the Lucifer's vessel.

Season 3 marks a significant turning point in the series, as Sam and Dean face off against Lucifer, the fallen angel. The season introduces new characters, including Castiel (Misha Collins), an angel who becomes a key player in the show.

Season 7 sees Sam and Dean facing off against a new enemy: the Reapers. The season also explores the show's mythology, including the introduction of the Men of Letters.